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Granulocytic sarcoma after stem cell transplantation in a child with biphenotypic leukemia
Granulocytic sarcoma is an extramedullary tumor composed of leukemic blasts. Isolated granulocytic sarcoma has rarely been reported in children with leukemia undergoing allogeneic stem cell transplantation. We report a case of isolated granulocytic sarcoma arising from the pleura in an 11-year-old girl who was previously treated for biphenotypic leukemia with allogeneic stem cell transplantation. Complete resolution of the tumor was achieved after two inductions with MRC 12 protocol; however, she died of sepsis during the neutropenic period. The unusual presentation, immunophenotypic differences at diagnosis and relapse, and the management options are discussed.

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Authors: Zühre Kaya, Ülker Koçak, Meryem Albayrak, Türkiz Gürsel, Nalan Akyürek, Suna Özhan Oktar

Keywords: İzole granulositik sarkom, kök hücre nakli, relaps

  • Year: 2009
  • Number: 3
  • Referance No: 37232

  • Figure 1. A. Tumoral infiltrate composed of blastic cells with narrow cytoplasm, round to oval nuclei and prominent small nucleoli displaying open chromatin pattern (hematoxylin-eosin, x400); B. Blastic cells show CD43 positivity (CD43, x400); C. Blastic cells show focal MPO positivity (MPO, x400)
  • Figure 2. A. Axial CT scan showing a large pleural-based soft tissue lesion with regular contours in the upper lobe of the left lung; B. Control CT examination shows a significant decrease in the size of the lesion

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