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“Niche” concept and the hematopoietic stem cell niches
A stem cell niche is defined as the most suitable tissue microenvironment where somatic cells (parent cells) or in some cases extracellular matrix elements and stem cells are present in an exclusive interaction. In recent years, promising data were published revealing the molecular and functional significance of cell-cell contacts in stem cell proliferation (self-renewal) and differentiation into mature cells. In this brief review, recent progress has been documented with special emphasis on the structural-functional relationship between stem cells and surrounding cells. Hematopoietic stem cells and their niches are among the most studied stem cell types and cell-cell interactions, which have specific as well as some common properties observed in other niche sites in the human body. Some of the signaling pathways, which are illustrated by original drawings herein, obviously play major roles in stem cell self-renewal capacity and differentiation status. Therefore, stem cell niches stand as the most critical biological sites in stem cell physiology and could also be considered as the new targets for the treatment of certain diseases.

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Authors: Alp Can

Keywords: Hematopoetik kök hücreleri, kök hücresi, niş, Notch sinyali, Wnt sinyali

  • Year: 2007
  • Number: 3
  • Referance No: 85856

  • Figure 1. Two types of niches are defined depending on the existence of parent cells adjacent to stem cell(s). A. Multicellular niche is typically composed of two or more types of parent cells interrelated with each other and with stem cells (arrows). They build several intercellular adhesion sites and molecular signaling pathways providing a suitable niche environment. B. Acellular (extracellular matrix) niche is characterized as the expression of certain cell adhesion molecules on the stem cell surface which interact with specific extracellular matrix proteins (arrows). ECM: Extracellular matrix (original drawing by A. Can).
  • Figure 2. N-cadherin (+) cell adhesion sites (small rectangle between osteoblast and hematopoietic stem cell, HSC) stimulate the Wnt/ß-catenin signaling pathway, which induces HSC proliferation while significantly inhibiting their differentiation, thereby resulting in functional selfrenewal (Original drawing by A. Can).
  • Figure 3. Notch signaling executed by a series of highly conserved receptors is a key factor in inhibiting differentiation. Intact Notch signaling is required for Wnt-mediated maintenance of undifferentiated HSCs. Notch signaling is active in HSCs and downregulated as HSCs differentiate. Inhibition of Notch signaling leads to accelerated differentiation of HSCs (Original drawing by A. Can).

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