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t(1;3)(p36;p21): presentation of a patient with MDS/AML (M2) and review of the literature
t(1;3)(p36;p21) is a recurrent reciprocal translocation found in a subset of myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) characterized by trilineage dysplasia, especially dysmegakaryopoiesis and poor prognosis. In the literature, some authors have suggested that this recurrent translocation is closely associated with prior chemotherapy including alkylating agents in various hematologic malignancies. We identified a recurring translocation, t(1;3)(p36;p21), in our patient with MDS/AML(M2), although she had not been given any kind of treatment previously.

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Authors: Gülgün S. Güven, Yelda Tarkan Argüden, Şeniz Öngören, Ayhan Deviren, Yıldız Aydın, Seniha Hacıhanefioglu

Keywords: Myelodisplastik Sendrom (MDS), Akut Myeloid Lösemi (AML), translokasyon, 1. kromozom, 3. kromozom

  • Year: 2006
  • Number: 2
  • Referance No: 02259

  • Figure: ???????????

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