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Imatinib mesylate and the management of chronic myeloid leukemia (CML)

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Authors: Ebru Koca, İbrahim C. Haznedaroğlu

Keywords:

  • Year: 2005
  • Number: 4
  • Referance No: 09406

  • Figure 1. Philadelphia chromosome of chronic myeloid leukemia (CML). The reciprocal balanced translocation of genetic material between the long arms of chromosomes 9 and 22 t(9;22)(q34;q11).
  • Figure 2. The formation of BCR/ABL fusion transcripts based on the translocation between ABL and BCR genes, and their encoded cytoplasmic proteins (P190, P210, P230).
  • Figure 3. The reciprocal translocation between chromosomes 9 and 22 t(9;22)(q34;q11), causes the formation of a new hybrid gene (BCR/ABL) that codes for a 210 kb cytoplasmic protein (P210) that by autophosphorylation activates a number of signalling pathways involved in cell proliferation, maturation, apoptosis and adhesion, leading to the malignant cell transformation in chronic myeloid leukemia (CML).
  • Figure 4. Marked bone marrow myeloid hyperplasia in the chronic phase chronic myeloid leukemia (CML).
  • Figure 5. Blastic infiltration of the bone marrow in the blastic transformation phase of chronic myeloid leukemia (CML).
  • Figure 6. An algorithmic approach to the frontline therapy of Philadelphia positive chronic phase chronic myeloid leukemia (CML) (CG; Cytogenetic, HHT: Homoharringtonin, SCT: Stem cell transplantation, FTI: Farnesyl transferase inhibitors, TKI: Tyrosine kinase inhibitors)

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