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Immunosuppressive Therapy-Induced Hepatotoxicity in Patients with Aplastic Anemia
Immunosuppressive therapy is a treatment for aplastic anemia patients who are not candidates for hematopoietic stem cell transplantation. The aim of the study to evaluate the frequency and severity of immunosuppressive therapy-induced hepatotoxicity in patients with aplastic anemia. The records of 27 patients with aplastic anemia who had eceived immunosuppressive therapy were received and determined for evidence of hepatotoxicity. The patients were divided into three groups. Group 1 was treated with antithymocyte/antilymphocyte globulin and cyclosporin A, group 2 received onl yyclosporin-A and group 3 was treated with antithymocyte/antilymphocyte globulin + cyclosporin-A and granulocyte macrophage colony-stimulating factor. All patients in group 1 had an initial increase in AST and ALT levels after therapy, but these tests abnormalities returned to normal in each case (p> 0.05). There was no detectable change in AST and ALT levels in group 2 (p>0.05). In group 3, five patients had an increase in ALT and AST levels in the initial several days after therapy was started but he levels gradually returnedto normal by the second or third week of therapy.

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Authors: İmdat Dilek, Ramazan İdilman, Semin Fenkçi, Celalettin Üstün, Haluk Koç, Osman İlhan, Hamdi Akan

Keywords:

  • Year: 2000
  • Number: 3
  • Referance No: 52279

  • Figure 1a. Serum AST levels pre and post-immunosuppressive therapy. Normal range of AST 0-40 IU/L.
  • Figure 1b. Serum ALT levels pre and post-immunosuppressive therapy. Normal range of ALT 0-40 IU/L.
  • Figure 2. The characterization of ALT level of patient who died during immunosuppressive therapy

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