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Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature
Cup-like morphology is defined as cup-like nuclear invagination spanning ?25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative.

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Authors: Özgür Mehtap, Elif Birtaş Ateşoğlu, Emel Gönüllü, Hakan Keski, Abdullah Hacıhanefioğlu

Keywords: ALL, AML, cup-like blast, FLT3 ITD

  • Year: 2011
  • Number: 2
  • Referance No: 57614

  • Figure 1. Cup-like blasts
  • Figure 2. MPO negativity and CD20 positivity in bone marrow

Copyright © 2013 TJH Atlas of Hematology. All rights reserved.