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  • Effects of Desialylation on Chemoattractant Induced Chemotaxis
    Figure 1. Effect of NANase on PMN chemotaxis. Each bar represents mean (± SE) percent migration of PMNs treated for 0.5 h with increasing concentrations of NANase (open bars) or media alone (closed bar) across naked filters in response to IL-8 (100 ng/mL) (A), PMNs treated for increasing times with NANase (10 mU/mL) (open bars) or media alone (closed bar) (B). The “n” for each group is indicated in each bar. * Significantly decreased compared to the simultaneous media controls at p
  • Effects of Desialylation on Chemoattractant Induced Chemotaxis
    Figure 2. Effect of NANase on PMN chemotaxis with various chemoattractants. Each bar represents mean (± SE) percent migration o PMNs treated for 0.5 h with either NANase (10 mU/mL) (closed bars) or media alone (open bars) across naked filters in response to IL-8 (100 ng/mL), fMLP (10-9 M), C5a (1/60 dilution), LTB4 (10-9 M) and media alone. The “n” for each group is indicated in each bar. * Significantly decreased compared to the simultaneous media controls at p
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