ISSN: 1300-7777 E-ISSN: 1308-5263
Immunohematological characteristics of Nigerian sickle cell disease patients with osteomyelitis [Turk J Hematol]
Turk J Hematol. 2008; 25(3): 145-148

Immunohematological characteristics of Nigerian sickle cell disease patients with osteomyelitis

Elkanah Ayodele Orimolade1, Lateef Salawu2
1Department Of Orthopaedics & Traumatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-ıfe, Nigeria
2Department Of Haematology & Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-ıfe, Nigeria

OBJECTIVE: We aimed in this paper to investigate some immunohematological characteristics of Nigerian sickle cell anemia (SCA) patients with osteomyelitis.
METHODS: Thirty SCA patients with osteomyelitis (SO) and 30 SCA patients without osteomyelitis (S) were investigated. The PCV, WBC and platelet count were done on automated counter, while the erytorocyte sedimentation rate (ESR) was determined by Westergren’s technique. C3 activator, C1-INH, IgA, IgG and IgM were estimated by the single radial immunodiffusion method.
RESULTS: The SO patients weighed less (z =1.943, p<0.055) and were shorter (z = -2.064, p<0.039). High serum levels of IgG, IgM, C1-INH and C3 activator were also found in the SO group. ESR correlated positively with hematocrit (r=0.371, p<0.04) and C3 activator (r=0.468, p<0.03) in SO. Similarly, WBC correlated positively with C1-INH
(r=0.806, p<0.01), while we also noted positive correlation between C1-INH and C3 activator (r=0.525, p<0.02). In SO, ESR correlated positively with both IgM (r=0.531, p<0.02) and C3 activator (r=0.449, p<0.05).

CONCLUSION: This study suggests some derangement in immune status in Nigerian SCA patients with osteomyelitis and that C1-INH and C3 activator may be useful markers of immune status in SCA patients.

Keywords: Bone, bacterial infection, hemoglobinopathy, osteomyelitis, sicle cell anemia.


Osteomiyeliti olan Nijeryalı orak hücre hastalığına sahip kişilerin immünohematolojik özellikleri

Elkanah Ayodele Orimolade1, Lateef Salawu2
1Department Of Orthopaedics & Traumatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-ıfe, Nijerya
2Department Of Haematology & Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-ıfe, Nijerya

AMAÇ: Osteomiyeliti olan Nijeryalı orak hücre anemisine sahip kişilerin immünohematolojik özelliklerinin araştırılması.
YÖNTEMLER: Osteomiyeliti olan 30 Sickle Cell Anemi (SCA) hastası (SO) ve osteomiyeliti olmayan 30 SCA hastası (S) araştırılmıştır. Eritrosit sedimentasyon hızı (ESR), Westergren tekniğiyle belirlenirken PCV, WBC ve trombosit sayımı otomatik bir sayaçla yapılmıştır. C3 aktivatör, C1-INH, IgA, IgG ve IgM tek radial immünodiffüzyon yöntemi ile hesaplanmıştır.
BULGULAR: SO daha hafif (z = 1,943, p<0.055) ve daha kısadır (z = -2,064, p<0.039). SO’da IgG, IgM, C1-INH ve C3 aktivatör serum seviyeleri yüksektir. SO’da ESR, hematokrit (r=0,371, p<0,04) ve C3 aktivatör (r=0,468, p<0,03) ile pozitif olarak koreledir. Benzer şekilde WBC, C1-INH (r=0,806, p<0,01) ile pozitif olarak koreledir. Ayrıca C1-INH ve C3 aktivatör (r=0,525, p<0,02) arasında da pozitif bir korelasyon belirledik. SO’da ESR, IgM (r=0,531, p<0,02) ve C3 aktivatör (r=0,449, p<0,05) ile pozitif olarak koreledir.
SONUÇ: Bu çalışmaya göre, osteomiyeliti olan Nijeryalı SCA hastalarının immün durumu biraz karışıktır ve C1 INH ile C3 aktivatör, SCA hastalarındaki bağışıklık durumunun faydalı belirteçleri olabilir.

Anahtar Kelimeler: Kemik, bakteriyel enfeksiyon, hemoglobinopati, osteomiyelit, orak hücreli anemi.


Elkanah Ayodele Orimolade, Lateef Salawu. Immunohematological characteristics of Nigerian sickle cell disease patients with osteomyelitis. Turk J Hematol. 2008; 25(3): 145-148

Corresponding Author: Lateef Salawu, Nigeria


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